BBC Inside Science Folgen

Proteomes, the sequences of protein within the DNA of every living thing, are notoriously difficult to model. The usual chemical methods can take months, but a new computational model using the ability of artificial intelligence to learn the complex sequences is able to predict structures within a matter of hours. Thousands of protein structure predictions are now available on a public database for anyone to access. Understanding such proteins is seen as key to treating nearly all disease. It also hold the potential for improvements in fields as diverse as increasing crop resilience to climate change and biodegrading plastic on an industrial scale. Marnie Chesterton speaks with Demis Hassabis from Deepmind which developed the protein structure prediction system, and Janet Thornton from the European Bioinformatics Institute which holds the database.Genetic engineering, the promise and perils, is the subject of a new series with Matthew Cobb on Radio 4, called Genetic Dreams, Genetic Nightmares. He tells us about the dilemmas now faced by researchers who on the one hand have the potential to send terminator genes into malaria spreading mosquitoes – but who are also aware of the huge unknowns surrounding the release of such technology.Extreme weather events are becoming more frequent. Hayley Fowler has been researching the links between weather systems, climate change and the heat and floods we are currently experiencing.And could we reduce the incidence of SARS-Cov2 with a different vaccination strategy? Julia Gog has modelled different scenarios, as the number of infections continues to rise. A strategy to target those who are mixing the most, whether socially or through their employment, may be more effective than one targeting the most vulnerable.

Epidemiologist Julian Peto is advocating mass testing as the key part of a plan to stop the virus spreading. Studies where everyone has been tested have picked up asymptomatic cases. With the addition of isolation and contact tracing this method of testing has been able to massively reduce the spread of the virus. The hope is such a coordinated scheme implemented nationally could help bring the numbers down.There’s a question over which type of test is best to use for mass testing. At the moment many of us do lateral flow tests at home. Although they give instant results their accuracy has been shown to be strongly linked to how well the tests are conducted - hence the need to back up any positive findings with the more accurate PCR test. PCR takes longer and needs sophisticated lab equipment. However a compromise could be to use RT Lamp tests, they are accurate, give results in around 20 minutes, do require a very basic lab, but without the expensive equipment of PCR. A number of RT lamp tests have now been developed for SARS-Cov2. Kevin Fong has been to see the developers of one of them, the OxLAMP test. And with the lifting of restrictions how are you going to judge your own personal risk from Covid? It’s a question that interests philosopher of science Eleanor Knox. She says government mandates on mask wearing and social distancing have allowed us to avoid tricky questions around our own potential risk from the virus and risks our own behaviour might pose to loved ones. Now there’s a lot more to think about in terms of balancing our desires to return to some semblance of normality while levels of Covid infection continue to rise. One area that’s come into sharp focus over lockdown is exercise. Some people have been unable to exercise due to Covid restrictions while others have discovered a whole new interest in moving more. A new book ‘Move’ by Caroline Williams explores the links between brain function, evolution and movement. She says staying active is a fundamental part of what makes us human.

A global project looking at the genomes of over 2 million people has found a number of distinct genetic markers which seem to either make Covid infection more likely or the symptoms more severe. Some of these markers are known to be associated with susceptibility to cancer and lung disease. However the researchers say on their own these genetic factors are not determinants of how sick people will become. Underlying health, age and sex and a range of environmental and social factors are likely more important says Andrea Ganna from Finland’s Institute of Molecular Medicine who crunched the numbers.The Royal Society Summer Exhibition has just opened. And this year its an opportunity for more people to get involved than ever before – the event is taking place online. There are a number of workshops and interactive games. We speak to a couple of the participants. Caroline Orr from Teesside University talks about research using supercomputers to make microbes produce a range of biofuels that could replace petrol and diesel, and Tony Peyton from Manchester University tells us how the electromagnetic properties of materials are bring harnessed to improve mine clearance in former war zones. And we go to another exhibition, the Royal College of Art graduate show, and ask the age old question - is it art ? Students Kukbong Kim and Bahareh Saboktakin show us their work with recycled concrete and 3d printing - which looks more like science to us.