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BBC Inside Science

A weekly programme that illuminates the mysteries and challenges the controversies behind the science that's changing our world.

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  • Folge vom 25.07.2019
    False positives in genetic test kits, Impact of fishing on ocean sharks, Sex-change fish
    Dr Adam Rutherford uncovers the worrying number of false positive results that the DNA sequencing technologies used by 'direct to consumer' genetic test kits are producing. Many of these tests offer analysis on your ancestry, but some also offer to check you out for the likelihood of you being at risk of some genetic diseases like cystic fibrosis or certain types of breast cancer. The tests look for variants in your genome, little changes in your DNA that alter the risk of developing a number of genetic diseases. The trouble is the rarer the variant, the more likely it is to be disease-causing. But the rarer the variant, the more likely the simple genetic tests are to get it wrong. And with more and more people sending off their raw genetic data to third-party websites for analysis and annotation, the risk of a false positive result increases to up to 80%. It's a small number of people affected, but a serious one if you're told out of the blue that you are at extreme risk of a serious disease. The advice is to keep an eye on family disease traits and if you are worried, go and see your doctor and get a proper diagnostic test.Deep sea pelagic sharks, like the great white, silky, tiger, porbeagle and blue are much more vulnerable than their scary reputation suggests. In fact, many shark species are in decline as a result of industrial fishing rapidly encroaching upon their territories, and an increased value of the sharks themselves. The oceans are big and sharks range far and wide, so understanding these movements is not easy. Professor David Sims, from the Marine Biological Association of the UK and the National Oceanography Centre in Southampton, is part of a huge international consortium of marine biologists who have been tracking 11 species of shark all over the high seas using satellite technology. We’ve been fishing for more than 40,000 years, but our exploitation of the seas got serious in the last 50 years.In nature, sex can be quite fluid, and in some species, sex changes are just a normal part of every day life. Especially in fish. This type of behaviour is called sequential hermaphroditism, and is common in fish. It's been known about for years, but the underlying genetic mechanisms are mysterious, which is strange for such a radical transformation. In the Blueheaded wrasse, when a dominant male is lost from the shoal, the largest female will immediately begin transforming into a male. Neil Gemmell from the University of Otago in New Zealand has lead a study which for the first time has uncovered the genetics of how the sex change happens.Producer: Fiona Roberts
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  • Folge vom 18.07.2019
    Turing on the new £50 note, Moon landing on the radio, 25 years since Shoemaker-Levy comet
    Code-breaker and father of computer science, Alan Turing has been chosen to celebrate the field of science on the new £50 note. Adam Rutherford asks Chief Cashier at the Bank of England, Sarah Johns how and why he was selected and he asks Sue Black, Professor of Computer Science and Technology Evangelist at Durham University, who campaigned to save Bletchley Park, what this accolade means.In 1969, while millions watched the Apollo 11 moon landing on the television, BBC radio was providing scientific and engineering commentary throughout the day. One young scientist brought in to help interpret the lunar landscape was Lionel Wilson, at the time he had just finished his PhD on the mechanics of the Moon's surface. But after seeing evidence of ancient lava fields in the pictures beamed back to Earth, he changed the course of his career and spent the next 50 years studying volcanology on Earth and in space.25 years ago, the planet Jupiter was peppered with over 20 cometary impacts, this had never been seen before. The comet was Shoemaker Levy 9, which had already broken into icy pieces. Its fiery death had been foretold a year earlier when calculations showed its orbit was due to cross Jupiter's. As D-day approached, July 16 1994, experts wondered whether there would be fireworks, or a fizzle, they weren't disappointed.Producer - Fiona Roberts
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  • Folge vom 11.07.2019
    Earliest modern human skull, Analysing moon rocks, Viruses lurking in our genomes
    A new study shows that 210,000-year-old skull found in Greece is the earliest evidence for modern humans in Eurasia. A second skull found in the same site is found to be a Neanderthal from 170,000 years ago. These findings suggest that modern humans left Africa earlier and reached further than previously thought. Analysing moon rocks The Apollo missions were scientific explorations, bringing back hundreds of kilograms of moon rock to help us understand the formation of the Moon, the Earth and life itself. We are still studying the rocks that were bought back from between 1969 and 1972. Roland Pease went to the Diamond Light Source Syncotron in Oxfordshire, where scientists are still studying these moon rocks. Viruses lurking in our genomes When it comes to our genomes, there is no such thing as 100% human. Our genetic code is a patchwork of DNA that we have picked up or lost along the way. 8% of our DNA comes from viruses. So what does this mean? Much of the viral DNA is thought to have been involved in forming our immune systems, fighting against pathogenic viruses. But it's not all good news, new work suggests that these human endogenous retroviruses or HERVs might also be the missing causative link in major 'unsolved' neurological diseases such as multiple sclerosis [MS], amyotrophic lateral sclerosis, or Lou Gehrig's disease [ALS] and schizophrenia [SCZ].Presenter: Adam Rutherford Producer: Caroline Steel
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  • Folge vom 04.07.2019
    X-Rays on Mercury, Monkey Tools, Music of Molecules, AI Drivers
    The 2019 Royal Society Summer Science exhibition in London is free to enter and continues until Sunday 7th July. BBC Inside Science this week comes from the Society’s HQ in central London.BepiColombo and the X-rays from Mercury Prof Emma Bunce, has been part of the team that last year launched an x-ray telescope on a space probe to Mercury. It will be a long journey, not arriving until 2025. As Emma describes, the MIXS instrument, designed and built in the UK, will analyze the x-rays emitted by the different chemicals on the planet’s surface, and so build a map of the abundancies of different atoms across the terrifyingly hostile world. This is only possible because of the strength of the x-rays coming from the sun that strike the atoms on the surface, eliciting a distinctive signature re-emitted back into space.Capuchin Monkeys and their Tools Tomos Proffitt and colleagues announced in a recent paper in the journal Nature Ecology and Evolution their study of archaeological evidence of Brazil’s capuchin monkeys using stones and anvils to smash cashew nuts for at least the last 3000 years. It is not the oldest evidence of non-human primate tool use but it is the oldest for monkeys, and suggests tantalisingly that tool use may have emerged in hominin species independently and on numerous occasions.Molecular Music Chemistry and music pupils at Ilkley Grammar School in the UK have been working together with The University of Bradford to create music specific to different molecules. As A-Level students Amelia Milner and Matthew Hodson describe to Adam, they took the distinctive frequencies of the bonds in certain molecules found in nature and transposed them onto the chromatic musical scale. Then the musicians composed pieces using only that set of notes that evoked some of the properties of the molecules. AI Drivers and Machine Learning Genovefa Kefalidou shows Adam a self-driving car circling a track at the exhibition. The technology to identify and track different objects is getting better, and machine learning algorithms can map human actions onto different scenarios to find appropriate responses, but is society ready to trust and accept the benefits they might bring?Presenter: Adam Rutherford Composers: Amelia Milner, Matthew Hodson (water, aspirin) and Daniel Burgess (cinnamic acid) Producer: Alex Mansfield
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