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Andrew Marr talks to the forensic psychotherapist Dr Gwen Adshead about the medicalisation of evil. While human nature in a different guise is explored through William Boyd's literary everyman, Logan Mounstuart, who moves from the page to tv screen in the adaptation of his novel, Any Human Heart. The poet Craig Raine compares the composition of a poem to the art of dress-making: "We are waiting till it feels exact,/ ruthless till we feel the fit." And the psychiatrist Iain McGilchrist concludes that the problem with modern society can be found in the left side of our brain. Producer: Katy Hickman.

Andrew Marr talks to the Swedish poet, Lars Gustafsson about whether writers have a responsibility to challenge the establishment. Gillian Tett, the award-winning Financial Times journalist, who predicted the financial crash, does her own challenging of the status quo. The writer Patrick Wilcken describes the great intellectual Claude Levi-Strauss, as 'the poet in the laboratory' in a new biography. And Ed Vulliamy reports, in almost anthropological detail, on the lives of those caught up in the war of drugs, gangs and guns on the US-Mexican border. Producer: Katy Hickman.

Andrew Marr looks at what the future holds for Ireland after the financial crisis, with the cultural commentator, Fintan O'Toole, who argues for wholesale reform of the political system. While the Conservative MP, Nick Boles puts forward his blueprint for a new Britain. The fate of Deborah Cadbury's family firm was sealed when it was bought out by an American company. But she looks back at a chocolate dynasty that mixed sweet success with bitter rivalry. And the cellist Steven Isserlis is on a mission to enhance the reputation of the much-maligned composer, Saint-Saens.Producer: Eleanor Garland.