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Reports of a mental health epidemic among young people both leading up to and during the pandemic are now widespread. Sally Holland is the Children’s Commissioner for Wales and a former social worker. She tells Andrew Marr that mental health services in Wales, and the rest of the UK, need a serious rethink, because too many children are waiting too long for help.But the health researcher and psychologist Lucy Foulkes asks whether we have become fixated with labelling the stresses and challenges of human experience as a mental disorder. In Losing Our Minds she explains what is known about mental health problems, and why they so often appear during adolescence. But she argues that it’s vitally important to distinguish between ‘normal’ suffering and actual illness. Defining what is and isn’t an illness is also the subject of Suzanne O’Sullivan’s latest book The Sleeping Beauties – And Other Stories of Mystery Illness. Here the neurologist looks at startling cases of what appear to be psychosomatic illnesses which have infected groups of people – from refugee children in Sweden unable to wake up, to American high school students having seizures, to mass headaches and memory loss in the US embassy in Cuba. O’Sullivan looks at how far these disorders are influenced by societal forces and human biology.Producer: Katy Hickman

Tom Tugendhat MP is the Conservative chair of the Foreign Affairs Committee. He tells Andrew Marr that he’s very much focused on British foreign policy priorities after Brexit. But the government’s new Trade Bill is facing opposition from those insisting that human rights abuses must be investigated before any deals are done. The MP for Tonbridge and Malling also highlights the need to be more aware of China’s economic ambitions and global role. Geeta Tharmaratnam is keen that more focus should be placed on Africa. As a venture capitalist and CEO of an investment company she see huge economic possibilities across the continent, especially in relation to African women entrepreneurs. She looks more closely at the African Continental Free Trade Area which was signed by a majority of countries in Kigali, Rwanda in 2018 and came into force this year.But the journalist Michela Wrong questions whether the Rwandan government, and especially its much feted leader President Paul Kagame can be trusted. Following the civil war and genocide in 1994 Kagame became vice-President and then leader of his country. He has prioritised national development and been successful in securing international aid, but Wrong follows the story of his rise to power and argues that he has overseen a regime intent on political repression.Producer: Katy Hickman

Edward St Aubyn is the award-winning author of the Patrick Melrose series. His new novel, Double Blind, also revolves around transformation and the headlong pursuit of knowledge. He tells Tom Sutcliffe that his characters range across the sciences – from genetics to ecology to psychoanalysis. And their investigations into inheritance, freedom and consciousness intertwine with their feelings of love, fear and greed.Isaac Newton is often revered as the scientific genius of the 18th century: an unworldly scholar who abandoned his intellectual life to rescue the country’s finances. But the academic Patricia Fara paints a more complicated picture in Life After Gravity. Here Newton is seen in the last 30 years of his life as he heads both the Royal Mint and the Royal Society – a scientist who revelled in the dirty worlds of money and politics. Chris van Tulleken is an infectious diseases doctor who has also forged a career presenting health and science programmes on radio and television. With his twin brother Xand he has put competing health theories to the test, and shared his own personal experience of Covid 19. In his new series for Radio 4, The Jump, he investigates the latest scientific evidence looking at how animal viruses spread to humans, and how far human behaviours are causing pandemics.Producer: Katy Hickman