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400 years ago Robert Burton produced his labyrinthine masterpiece, The Anatomy of Melancholy – a work which was celebrated in the Renaissance for its understanding of the huge variety of causes, symptoms and cures of mental distress. In A User’s Guide To Melancholy the academic Mary Ann Lund looks back to this precursor of the self-help book. She tells Amol Rajan that we have much to learn from those who struggled with melancholy in the past.In Heavy Light, the writer Horatio Clare shares how his mind began to unwind; his growing mania followed by psychosis and his treatment in a psychiatric hospital. But he also details the journey of recovery and healing, and he investigates how society treats acute crises of mental health.The psychiatrist Ahmed Hankir understands only too well what it’s like to feel depressed and hopeless – he suffered from mental health difficulties during his studies. He has used his own experiences to produce The Wounded Healer which seeks to reduce stigma around mental health, blending psychiatry and the performing arts.Producer: Katy Hickman

The deep sea is the last, vast wilderness on Earth. In The Brilliant Abyss the marine biologist Helen Scales dives below the surface to tell the story of our relationship with the ocean floor. With an average depth of 12,000 feet it remains a frontier for new discoveries and extraordinary creatures. But Helen Scales warns Andrew Marr of the unfolding environmental disasters as people seek to exploit this new world, far beyond the public gaze.The writer Philip Hoare explores nature through the work of the artist Albrecht Dürer. From his 15th century prints of the plague-ridden Apocalypse to his leviathans in the deep, Dürer’s works were a revelation. In Albert & the Whale Hoare writes about the enduring quality of his art and its powerful message about the fragile beauty of the natural world.The journalist Elizabeth Kolbert is the author of the international bestseller, The Sixth Extinction, which was a clear-eyed account of humanity’s impact on the Earth. In Under A White Sky she asks whether through scientific innovation we can reverse some of the damage done. She meets those re-engineering ‘super coral’ which can withstand hotter waters and those tasked with saving the rarest fish species in the world.Producer: Katy Hickman

Kerri ní Dochartaigh was born in Derry-Londonderry at the height of the Troubles, to a Catholic mother and Protestant father. In Thin Places she traces a life affected by poverty, loss and violence, and the invisible border that runs through it. But she tells Kirsty Wark how the natural world has helped heal the traumas of childhood.For the writer Sally Bayley it was Shakespeare that brought her solace and ignited her imagination. Growing up in a working class household with no father figures Bayley roamed through his plays looking for companions and escape from her oppressive home. In No Boys Play Here: A Story of Shakespeare & My Family’s Missing Men she explores the crisis of male homelessness and mental illness.The award-winning actress Lisa Dwan has a deep affiliation with the works of Samuel Beckett. But in her latest performance she reaches back to the ancient Greek tragedians reimagined by another acclaimed Irish writer Colm Tóibín. In Pale Sister she recounts Sophocles’ tragedy of Antigone from the viewpoint of her sister, Ismene. Producer: Katy Hickman