Vaccination has eradicated smallpox, a disease that decimated populations through the 20th century. Polio is almost gone too, and measles is no longer the pervasive childhood threat it once was. It’s clear that vaccination is our best tool to halt the threat of SARS CoV 2, and allow the return to a less restricted way of life. But it takes time to develop and test vaccines although the technologies used to create them have moved on significantly over the last few decades.Professor Jonathan Ball, a virologist at Nottingham University, talks Adam Rutherford through the several types of vaccine that are being explored in the effort to stop the coronavirus pandemic, and how they work. These include live attenuated virus vaccines that are genetically modified to appear to be SARS CoV 2 to the immune system, and RNA subunit vaccines that trick the body into recognising the virus. He discusses the way different vaccines work against disease, and how they trigger different types of immune response. Before a vaccine is approved for general use it has to pass through three trial phases, and Jonathan discusses the vaccines that are already going through phase 2 and 3 in the UK. If and when a vaccine gets approved, it needs to be produced to exacting standards and in quantities great enough to immunise the whole population. The UK Vaccine Manufacturing Taskforce was set up in May to coordinate the effort to make a vaccine. Steve Bagshaw, part of the Taskforce, explains that some vaccines have already been produced around the UK, prior to clinical approval in an effort to ensure that any approved vaccine is ready to be distributed as fast as possible to those at risk. This is unprecedented, and means the pathway to vaccine distribution could be faster than any that have gone before. Presented by Adam Rutherford
Produced by Fiona Roberts and Rory Galloway
Wissenschaft & Technik
BBC Inside Science Folgen
A weekly programme that illuminates the mysteries and challenges the controversies behind the science that's changing our world.
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Folge vom 10.09.2020Coronavirus: The types of vaccine; How the UK is scaling up vaccine production
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Folge vom 03.09.2020Bird and dinosaur skull evolution; the wonders of yeast and Science Museum mystery objectSkulls give researchers a great deal of insight into how an animal might have evolved, and skulls can be sensibly compared between species and groups of animals. The 10,000 species of bird around the world are what’s left of an even more diverse group, the dinosaurs. But research on their skulls has revealed that despite the birds’ exceptional diversity, they evolve far more slowly than their dinosaur relatives ever did. This is one of the findings of a huge skull mapping project at the Natural History Museum led by Anjali Goswami. Marnie Chesterton delights Adam Rutherford with what she has recently learned about the single-celled fungus that is yeast. She recently visited the National Collection of Yeast Cultures in Norwich, which stores hundreds of thousands of strains of yeast. She discovered that yeast is not only responsible for the production and subtle flavours of bread, yeast and chocolate, but also that some species of yeast can actually clean carbon dioxide from the air and can be used to feed livestock.The Science Museum Group looks after over 7.3 million items. As with most museums, the objects you see on display when you visit is only the tip of the iceberg of the entire collection. Up until now, many of the remainder (300,000 objects) has been stored in Blythe House in London. But now the collection is being moved to a purpose-built warehouse in Wiltshire. The move is a perfect opportunity for curators to see what’s there, re-catalogue long hidden gems and to conserve and care for their treasures. But during the process they have discovered a number of unidentified items that have been mislabelled or not catalogued properly in the past and some of them are just so mysterious, or esoteric, that the Science Museum needs the aid of the public to help identify them, and their uses. This week, Jessica Bradford, the keeper of collection engagement at the Science Museum is asking Inside Science listeners if they recognise, or can shed light on the possible use of the ‘glassware’ in the picture above. Send suggestions to Email: bbcinsidescience@bbc.co.uk or mysteryobject@sciencemuseum.ac.ukPresenter – Adam Rutherford Producers – Fiona Roberts & Rory Galloway
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Folge vom 27.08.2020What does the science say about the COVID risks of schools reopening? Dolphin ear autopsyOver the next couple of weeks almost all children in the UK will be back to school. But the pandemic hasn’t ended, and we are far from having a complete understanding of how this virus works, including how it is transmitted and how it affects younger people. Pretty much everyone is in agreement that kids need to be back at school, as the costs of not being physically in classrooms are great - for the education of kids, for their mental health, and for the finances of parents needing to work. But what does the science say about the risks for schools reopening? Will we see a rise in infections in younger people, and hot-spots for the wider community? Adam Rutherford discusses these issues with Paul Hunter, Professor of Medicine at Norwich Medical School, and he finds out from Professor Tim Spector if his Kings College COVID symptom tracker app can shed any more light on whether children display the same COVID symptoms as adults, or could we be missing infections in the young?Marnie Chesterton eavesdrops on an aquatic autopsy. We pollute the oceans with noise that has some serious effects on marine life. Remotely via video link up, Marnie witnesses a complex autopsy on the inner ear of a dolphin. She discovers how accurately the death of the sensory hair cells in a cetacean’s ear records the time of damage. Presenter – Adam Rutherford Producer – Fiona Roberts
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Folge vom 20.08.2020Smart bricks, The Royal Academy of Engineering awards for pandemic engineering solutions and detecting SARS-Cov-2 in sewageRed clay bricks are among the most ubiquitous building materials worldwide. Julio D'Arcy, a chemist at Washington University in St. Louis, Missouri, describes to Adam Rutherford how he and his team have turned ordinary house bricks into energy storage units that can power home electronic devices – thanks to the red iron oxide (rust) pigment and a conductive plastic nano-material infused into the bricks These new ‘smart bricks’ can be charged to hold electricity a bit like a battery.As the pandemic continues, we continue to try to find ways to manage it, treat the disease, detect it and cure it. As necessity is the mother of invention, we're currently witnessing some of the most intense periods of scientific innovation in the 21st century. And there have been some incredible discoveries, innovations and inventions in just the last 6 months. The Royal Academy of Engineering announced a special round of awards this week, to recognise the heroics of engineers, designers and scientists to help tackle this pandemic. Professor Raffaella Oconé is Chair of the Awards Committee at the Royal Academy of Engineering, and she told Adam about the range of much needed inventions to tackle COVID19. The current mantra of 'test, track and trace has so far had limited success in the UK. In part because of the difficulty of testing enough people, tracking their movements and tracing the spread of the virus. By the time someone is displaying symptoms and then being one of the few people to then get a test, they may have spread the virus to many people. But scientists across the UK and abroad are beginning to realise that maybe there might be a cheaper alternative, that gives even earlier warning of a spike in infection - by detecting the virus in sewage.Presenter: Adam Rutherford Producers: Fiona Roberts and Beth Eastwood