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BBC Inside Science

A weekly programme that illuminates the mysteries and challenges the controversies behind the science that's changing our world.

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  • Folge vom 16.07.2020
    Science Fraud & Bias, Immunity to COVID-19
    Science is all about self-reflection. Scientists constantly check themselves, share their work, and check each other’s data. But how robust is the science upon which civilisation is built, the science which has mapped genomes, cured diseases, split atoms and sent people to the moon? Adam talks to Stuart Ritchie, a psychologist from Kings College London, about his new book Science Fictions which explores everything from biases and human fallibility, to outright fraud. He also talks to microbiologist turned image sleuth, Elisabeth Bik, whose work is revealing that manipulated images appear in scientific papers shockingly often.Now we are several months into the COVID pandemic, scientists are beginning to share their first insights into whether people retain immunity to SARS-CoV-2 after they've had the disease COVID-19. At Kings College London, Senior Lecturer in Infectious Diseases, Katie Doores and her team tracked the antibody levels over the first months after infection with COVID-19. Their first preprint findings suggest a worrying pattern – antibodies against the virus begin to wane within months of being infected. However it is too early to say if and when a person who’s had COVID-19 could be vulnerable to reinfection. Early findings from Marcus Buggert, at the Karolinska Institute in Sweden, suggest that another part of the immune system, the memory T-cells, are active in those who have had the disease, even if they lack antibodies against the virus.Producers: Beth Eastwood & Fiona Roberts
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  • Folge vom 09.07.2020
    Satellite navigation in the UK; the science of the World Wide Web and Neolithic genomics
    Is the UK losing its way when it comes to satellite navigation? There's GPS from the US, but other countries and regions, including Russia, China, India and Japan, either have, or are building, satellite navigation systems of their own. The EU has Galileo, but with Brexit, Britain is no longer involved. The Government has announced that it’s just acquired a satellite technology company called OneWeb. It’s primary role is enhanced broadband, but there’s talk of adding in a navigation function to the constellation of satellites. But how feasible will that be? In an era of cyber-crime, misinformation, disinformation, state-sponsored attacks on rival countries’ infrastructure, government-imposed internet shutdowns in places like Eritrea and Kashmir, the World Wide Web is an increasingly dark and troubled place. Making sense of how the internet has changed from the democratic, sharing, open platform it was designed to be, and predicting what’s next, are the web scientists. Professor Dame Wendy Hall, Regius Professor of Computer Science at the University of Southampton, and a co-founder of the whole field of web science, is hosting an online, annual conference this week. The theme this year is 'Making the web human-centric'.Communal burial sites tend to suggest an egalitarian society, where everyone is considered equal. And this is what we expected the Neolithic societies that spread across Europe with the birth of agriculture around 6000 years ago would be. But DNA evidence from a single human, NG10, buried in 3200 B.C.E in the vast tomb of Newgrange, 25 miles north of Dublin, in Ireland, shows very strong inbreeding. Couple this with the fact the body was buried and not cremated and placed in a highly adorned chamber. Does this indicate an elite ruling class where marrying one’s close kin was the order of the day? Dr. Lara Cassidy, palaeogeneticist at Trinity College Dublin, decoded NG10’s DNA and she tells Adam Rutherford the story. Presenter - Gareth Mitchell Producers - Fiona Roberts and Beth Eastwood
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  • Folge vom 02.07.2020
    Preventing pandemics, invading alien species, blood types & COVID-19.
    As we’re beginning to understand more about SARS-CoV-2, the virus that causes COVID-19, we’re hopefully starting to get some clues on how to deal with the next viral pandemics, and even look at ways of stopping them from happening. To do this, we have to go back to where the virus jumped from its animal host into humans. Like this current coronavirus, many of the pandemic viruses (SARS, MERS HIV, Ebola…to name a few) are zoonotic diseases. They start in wild animals and evolve to jump to humans (sometimes via another animal species). It’s not the animal’s fault. It’s evolution. But has our tangled, often exploitative relationship with wild animals made it harder to stop future pandemics? A paper just published asks these questions and tries to figure out how to prevent future zoonotic epidemics. Dr. Silviu Petrovan (Researcher in the Department of Zoology in Cambridge) and Associate Professor Alice Hughes (Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences) highlight some of the 161 possible actions we should be taking to protect ourselves from the next pandemic.The current pandemic may have curtailed a lot of holiday plans but we are still more global than ever before. Food is coming to the UK from all over the world. With movement comes the opportunity for unwelcome hitchhikers to tag along. A new study, published in Biological Reviews, by a team of researchers from 13 different countries warns that alien species invasions are on the rise. Professor Tim Blackburn from University College London talks to Marnie about this increasing threat. Also on the programme, inspired by a listener question, Marnie asks whether there's any truth behind the idea that susceptibility to COVID-19 could be linked to blood type. Associate Professor of Venom Pharmacology at Reading University, Dr Sakthivel Vaiyapuri, explains what the science says so far.Producers: Fiona Roberts & Beth Eastwood
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  • Folge vom 25.06.2020
    The Human Genome Project's 20th Anniversary
    Adam Rutherford is back to celebrate the 20th anniversary of one of the most ambitious and revolutionary scientific endeavours of all time - the Human Genome Project. Its scope and scale was breath-taking, set up to read every one of the 3 billion nucleotides, or letters of genetic information, contained within the DNA in every cell of the human body. It took seven years, hundreds of scientists, cost almost $3 billion and, amazingly, came in under budget and on time. Adam reflects back on that momentous time with Ewan Birney, Director of the European Bio-informatics Institute, part of the European Molecular Biology Laboratory. Twenty years ago, he was a PhD student working on the project, in the months leading up to the first draft. The Human Genome Project underpins many branches of science, from human evolution and synthetic biology to forensic genetics and ancestry testing. But a key motivation for the project was to alleviate human suffering. While the ‘cures’, hyped by the media back in 2000, were not realistic our understanding of disease has been revolutionised. Adam talks to Cancer Research UK Scientist, Dr Serena Nik-Zainal, from Cambridge University, who explains why the sequencing of the human genome has been so crucial to the diagnosis and treatment of breast cancer. The Human Genome Project is also playing a crucial role in the COVID-19 pandemic. Dr Kenneth Baillie has been treating critically ill patients at Edinburgh’s Royal Infirmary since the pandemic started. As the Lead on GenOMICC, a global collaboration on genetics and critical illness, he has joined forces with Genomics England and the NHS, to pinpoint genetic signals in these patients to help identify the best treatments.Producers: Beth Eastwood & Fiona Roberts
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