Huberman Lab Folgen

This episode serves as a sort of “Dopamine Masterclass”. I discuss the immensely powerful chemical that we all make in our brain and body: dopamine. I describe what it does and the neural circuits involved. I explain dopamine peaks and baselines, and the cell biology of dopamine depletion. I include 14 tools for how to control your dopamine release for sake of motivation, focus, avoiding and combating addiction and depression, and I explain why dopamine stacking with chemicals and behaviors inevitably leads to states of underwhelm and poor performance. I explain how to achieve sustained increases in baseline dopamine, compounds that injure and protect dopamine neurons including caffeine from specific sources. I describe non-prescription supplements for increasing dopamine—both their benefits and risks—and synergy of pro-dopamine supplements with those that increase acetylcholine.  Read the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps 00:00:00 Introduction & Tool 1 to Induce Lasting Dopamine   00:05:04 Sponsors: AG1, LMNT & Waking Up 00:09:10 Upcoming (Zero-Cost) Neuroplasticity Seminar for Educators   00:09:58 What Dopamine (Really) Does   00:15:30 Two Main Neural Circuits for Dopamine   00:18:14 How Dopamine Is Released: Locally and Broadly   00:22:03 Fast and Slow Effects of Dopamine   00:25:03 Dopamine Neurons Co-Release Glutamate   00:28:00 Your Dopamine History Really Matters   00:30:30 Parkinson’s & Drugs That Kill Dopamine Neurons. My Dopamine Experience   00:36:58 Tool 3 Controlling Dopamine Peaks & Baselines   00:40:06 Chocolate, Sex (Pursuit & Behavior), Nicotine, Cocaine, Amphetamine, Exercise   00:46:46 Tool 4 Caffeine Increases Dopamine Receptors   00:49:54 Pursuit, Excitement & Your “Dopamine Setpoint”   00:56:46 Your Pleasure-Pain Balance & Defining “Pain”   01:00:00 Addiction, Dopamine Depletion, & Replenishing Dopamine   01:07:50 Tool 5 Ensure Your Best (Healthy) Dopamine Release   01:15:28 Smart Phones: How They Alter Our Dopamine Circuits   01:19:45 Stimulants & Spiking Dopamine: Counterproductive for Work, Exercise & Attention   01:22:20 Caffeine Sources Matter: Yerba Mate & Dopamine Neuron Protection   01:24:20 Caffeine & Neurotoxicity of MDMA   01:26:15 Amphetamine, Cocaine & Detrimental Rewiring of Dopamine Circuits   01:27:57 Ritalin, Adderall, (Ar)Modafinil: ADHD versus non-Prescription Uses   01:28:45 Tool 6 Stimulating Long-Lasting Increases in Baseline Dopamine   01:37:55 Tool 7 Tuning Your Dopamine for Ongoing Motivation   01:47:40 Tool 8 Intermittent Fasting: Effects on Dopamine   01:53:09 Validation of Your Pre-Existing Beliefs Increases Dopamine   01:53:50 Tool 9 Quitting Sugar & Highly Palatable Foods: 48 Hours   01:55:36 Pornography   01:56:50 Wellbutrin & Depression & Anxiety   01:58:30 Tool 10 Mucuna Pruriens, Prolactin, Sperm, Crash Warning   02:01:45 Tool 11 L-Tyrosine: Dosages, Duration of Effects & Specificity   02:05:20 Tool 12 Avoiding Melatonin Supplementation, & Avoiding Light 10pm-4am   02:07:00 Tool 13 Phenylethylamine (with Alpha-GPC) For Dopamine Focus/Energy   02:08:20 Tool 14 Huperzine A   02:10:02 Social Connections, Oxytocin & Dopamine Release   02:12:20 Direct & Indirect Effects: e.g., Maca; Synthesis & Application   02:14:22 Zero-Cost & Other Ways To Support Podcast & Research   Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Ph.D., Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We discuss the biology and medical clinical-trial uses of psilocybin, MDMA, ayahuasca, DMT, and LSD. Dr. Johnson teaches us what the clinical trials in his lab are revealing about the potential these compounds hold for the treatment of depression, addiction, trauma, eating disorders, ADHD, and other disorders of the mind. Dr. Johnson describes a typical psychedelic experiment in his laboratory, start to finish, including the conditions for optimal clinical outcomes. And he explains some of the potential hazards and common misconceptions and pitfalls related to psychedelic medicine. Dr. Johnson explains flashbacks, the heightened risks of certain people and age groups using psychedelics and the ever evolving legal and pharmaceutical industry landscape surrounding psychedelics. Dr. Johnson also explains how the scientific study of psychedelics is likely to set the trajectory of psychiatric medicine in the years to come. Dr. Johnson is among a small handful of researchers who have pioneered the clinical study of these powerful compounds. He has unprecedented insight into how they can be woven into other psychiatric treatments, changing ones sense of self and of reality. Read the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps 00:00:00 Introducing Dr. Matthew Johnson   00:02:27 Sponsors: AG1, LMNT & Waking Up 00:06:40 ‘Psychedelics’ Defined   00:14:09 Hallucinations, Synesthesia, Altered Space-Time Perception   00:19:56 Serotonin & Dopamine   00:23:50 Ketamine & Glutamate   00:28:00 An Example Psychedelic Experiment   00:37:30 ‘Letting Go’ with Psychedelics   00:44:10 Our Mind’s Eye   00:48:00 Redefining Your Sense of Self   00:58:56 Exporting Psychedelic Learnings to Daily Life   01:04:36 Flashbacks   01:12:10 Ayahuasca, ASMR, Kundalini Breathing   01:15:54 MDMA, DMT   01:26:00 Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis   01:38:15 Micro-Dosing   01:56:45 Risks for Kids, Adolescents & Teenagers; Future Clinical Trials   02:03:40 Legal Status: Decriminalization vs. Legalization vs. Regulation   02:18:35 Psychedelics for Treating Concussion & Traumatic Brain Injury   02:27:45 Shifting Trends in Psychedelic Research, Academic Culture   02:44:23 Participating in a Clinical Trial, Online Survey Studies, Breathwork   02:50:38 Conclusions, Subscribing & Supporting the HLP, Supplements   Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, I discuss ADHD (Attention-Deficit Hyperactivity Disorder): what it is, the common myths, and the biology and psychology of ADHD. I discuss both behavioral and pharmacologic treatments for ADHD, and brain-machine interface tools. I also discuss behavioral training protocols that can improve focus in people with ADHD and those without ADHD, and for people of different ages. I discuss the role of dopamine in coordinating 'default-mode' and 'task-related' neural networks, attentional "blinks" (lapses of attention) and how to overcome them, and the role of actual blinks in time perception and attention. Finally, I review some of the prescription and over-the-counter compounds for increasing focus such as Adderall, Ritalin, Modafinil and Armodafinil, the racetams, Alpha-GPC and phosphatidylserine and the role of diet for managing ADHD (and the controversies of diet for ADHD). The role of cell phones/technology in ADHD and ADHD-like challenges with focus are also discussed. Throughout, both basic science and clinical scenarios, as well as applicable tools and resources are covered. Read the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps 00:00:00 Introduction & Note About Diagnosis   00:03:44 Sponsors: AG1, LMNT & Waking Up 00:07:56 ADHD vs. ADD: Genetics, IQ, Rates in Kids & Adults   00:13:00 Attention & Focus, Impulse Control   00:14:57 Hyper-focus   00:16:45 Time Perception   00:18:25 The Pile System   00:20:00 Working Memory   00:24:10 Hyper-Focus & Dopamine   00:26:40 Neural Circuits In ADHD: Default Mode Network & Task-Related Networks   00:32:57 Low Dopamine in ADHD & Stimulant Use & Abuse   00:37:10 Sugar, Ritalin, Adderall, Modafinil & Armodafinil   00:47:00 Non-Prescribed Adderall, Caffeine, Nicotine   00:49:18 How Stimulants “Teach” the Brains of ADHD Children to Focus   00:52:00 When To Medicate: A Highly Informed (Anecdotal) Case Study   00:56:35 Elimination Diets & Allergies In ADHD   01:04:46 Omega-3 Fatty Acids: EPAs & DHAs   01:07:00 Modulation vs Mediation of Biological Processes   01:10:50 Attentional Blinks   01:16:56 Open Monitoring & 17-Minute Focus Enhancement   01:22:50 Blinking, Dopamine & Time Perception; & Focus Training   01:30:10 Reverberatory Neural & Physical Activity   01:33:40 Adderall, Ritalin & Blink Frequency   01:35:00 Cannabis   01:37:30 Interoceptive Awareness   01:41:15 Ritalin, Adderall, Modafinil, Armodafinil; Smart Drugs & Caffeine: Dangers   01:48:05 DHA Fatty Acids, Phosphatidylserine   01:50:54 Ginko Biloba   01:51:45 Modafinil & Armodafinil: Dopamine Action & Orexin   01:56:19 Acetylcholine: Circuits Underlying Focus; Alpha-GPC   01:59:04 L-Tyrosine, (PEA) Phenylethylamine   02:01:23 Racetams, Noopept   02:05:15 Transcranial Magnetic Stimulation; Combining Technology & Pharmacology   02:09:14 Smart Phones & ADHD & Sub-Clinical Focus Issues In Adults & Kids   02:14:30 Synthesis/Summary   02:16:10 Support for Podcast & Research, Supplement Resources   Disclaimer & Dislcosures Learn more about your ad choices. Visit megaphone.fm/adchoices