Science Friday Folgen

If given final approval by the FDA, this sickle-cell treatment would be the first to use gene-editing CRISPR technology on humans. Also, gene variants inherited from Neanderthals can impact pain tolerance in modern humans.  FDA Panel Clears Way For CRISPR-Based Sickle Cell TreatmentAn FDA committee cleared the way for a revolutionary cure for sickle cell disease this week. If given final approval, the treatment would be the first to use CRISPR gene editing in humans. Sickle cell disease is caused by a genetic mutation that causes blood cells to develop into crescent or “sickle” shapes. The extremely painful and often deadly disease disproportionately affects Black and African American people.Ira talks with Vox staff writer Umair Irfan about the new sickle cell treatment and other top science news of the week, including the link between the auto worker strike and a clean energy transition; new evidence about the moon’s origin; and why starfish don’t have arms. Your Pain Tolerance May Have Been Passed Down from NeanderthalsThere’s a little bit of Neanderthal in most of us. Neanderthals and Homo sapiens had a long history of intermingling, before the former went extinct about 40,000 years ago. That mixing means most modern humans have some amount of Neanderthal DNA—and it accounts for up to 3% of the genome in some people.While these genetic remnants don’t have much impact on our day-to-day lives, they may be responsible for one surprising effect: pain tolerance. Recent research shows that people with Neanderthal variants in the gene SCN9A have a lower pain tolerance than people without the gene.This isn’t the only Neanderthal remnant that’s been passed down. A study from earlier this year pinpointed a certain genome region that impacts nose shape. Taller, wider noses were passed down from our Neanderthal ancestors who lived in colder climates. A larger nose warmed air before it hit the sensitive lungs.Ira speaks with Dr. Kaustubh Adhikari, assistant professor of statistics at the Open University in the United Kingdom, who worked on both of these studies.  To stay updated on all things science, sign up for Science Friday's newsletters. Transcripts for each segment will be available the week after the show airs on sciencefriday.com.  Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

When you think of poisons, you might think of chemicals like cyanide, arsenic, or the deadly concoction left out for rats. But have you thought of acorns? What about the cup of coffee you had this morning? Or the mums growing in your window box? Toxicity is all in the eye—or bloodstream—of the beholder.A new book describes the story of nature’s endless array of toxins, and how they shaped life on earth, including ours.Guest host Flora Lichtman talks with Dr. Noah Whiteman, evolutionary biologist at University of California, Berkeley and the author of Most Delicious Poison: The Story of Nature’s Toxins – from Spices to Vices. They chat about the poisons that fill our pantries and gardens, and what our use and abuse of these substances tells us about ourselves.To stay updated on all things science, sign up for Science Friday's newsletters. Transcripts for each segment will be available the week after the show airs on sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Content warning: This interview includes discussion of miscarriage and pregnancy loss, and may be triggering for some listeners.The placenta is an incredible body part. It’s the only organ grown temporarily, created during pregnancy and discarded after birth. It has the enormous job of supporting the growth of a fetus, protecting it from infection and inflammation. When something goes wrong with the placenta, it can result in the loss of a baby.For something that can be so devastating to expectant parents, miscarriages are incredibly normal. Of the 5 million pregnancies each year in the United States, about 1 million end in miscarriage, categorized as a loss before 20 weeks of gestation. About 20,000 pregnancies end in stillbirth during the later stages of gestation.Often, after a pregnancy loss, doctors tell parents that the cause is unexplained. This can lead to feelings of failure and guilt, even though pregnancy loss is almost always out of a person’s control.Dr. Harvey Kliman, director of the Yale School of Medicine’s Reproductive and Placental Research Unit, has dedicated his career to better understanding the placenta and its relationship to pregnancy loss. Dr. Kliman and his team recently analyzed 1,256 placentas that resulted in pregnancy loss. They learned that 90% of these losses could be explained by conditions such as a small or misshapen placenta.Dr. Kliman joins guest host Flora Lichtman to talk about his research, and the importance of studying the placenta as a way to better understand what leads to miscarriage and stillbirth. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.