Science Friday Folgen

How Imperfect Data Leads Us Astray Datasets are increasingly shaping important decisions, from where companies target their advertising, to how governments allocate resources. But what happens when the data they rely on is wrong or incomplete? Ira talks to technologist Kasia Chmielinski, as they test drive an algorithm that predicts a person’s race or ethnicity based on just a few details, like their name and zip code, the Bayseian Improved Surname Geocoding algorithm (BISG). You can check out one of the models they used here. The BISG is frequently used by government agencies and corporations alike to fill in missing race and ethnicity data—except it often guesses wrong, with potentially far-reaching effects.     CRISPR Stops Rare Genetic Disease In New Human Trial When the gene-editing technique CRISPR first came on the scene in 2012, researchers were excited by the potential the technology offered for editing out defects in genetic code, and curing genetic diseases. The researchers behind the technique, Jennifer Doudna and Emmanuelle Charpentier, won a 2020 Nobel Prize.  In one of the first clinical applications of the technique, last month researchers reported in the New England Journal of Medicine that CRISPR had stopped a genetic disease called amyloidosis, which occurs when an abnormal protein accumulates in your organs. They’re not the only group moving toward using CRISPR on humans; recently, the FDA approved a human clinical trial that will use the technique to edit genes responsible for sickle cell disease.  Fyodor Urnov, a professor in the department of molecular and cell biology at the University of California at Berkeley and the director of the Innovative Genomics Institute, joins Ira to discuss the clinical trials, as well as what other therapeutic targets for CRISPR-based gene editing lie on the horizon.     Latinos In The West Are Twice As Likely To Be Affected By Wildfires  A housing crisis, mixed with the location of farmwork and frontline jobs that attract Latino residents, particularly migrant workers, have put the community at greater risk of being impacted by wildfires, California activists and experts say. According to reporting by Politico, which analyzed data from risQ, “The Latino population makes up about 18 percent of the U.S. but represents 37 percent of the people who live in the areas that risQ identified as facing the most extreme wildfire risks.” José Trinidad Castañeda, a climate activist in Orange County who serves as the Beautification and Environmental Commissioner for the city of Buena Park, says that in order to address the wildfire issue, California must address its housing crisis.  “Climate does not discriminate, but our housing crisis has,” said Trinidad Castañeda. Read the full story and listen to a conversation with Abbie Veitch, editor in chief at Currently.      Consider The Nocturnal, Whiskered Oilbird At first glance, the oilbird doesn’t seem so strange. It’s a chestnut-colored, hawk-like bird that lives in South America. But with a closer look, its strange qualities start to stack up. Oilbirds are nocturnal creatures that roost in caves in huge colonies. Sure, some other birds, like nightjays, do the same. But oilbirds also have a triple threat for navigating the darkness: They’re one of the few birds that use echolocation, they have incredible eyesight and sense of smell, and they have whiskers on their faces. Unlike bats, their ecolocating peers, oilbirds exclusively live off a fruit diet, confounding researchers looking into why they evolved so many specialized traits.  They also have an incredible screech—when deployed in large numbers, it’s easy to understand why local populations have given them a name that translates to “little devils." “It’s wrong in every way, as far as birds go,” says researcher Mike Rutherford, curator of zoology and anatomy at the Hunterian museum at the University of Glasgow in Scotland. Rutherford studied oilbirds in Trinidadian caves to learn more about their population sizes. “A lot of people say every species is unique, but some are more than others, and the oilbird is one of those.” Rutherford joins Ira and SciFri producer Kathleen Davis to make the argument that the oilbird deserves to be labeled a charismatic creature, and join the ranks of the Charismatic Creature Corner.   Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

President Biden’s Infrastructure Bill Sees The End Of The Road President Biden’s huge infrastructure bill is finally seeing the end of the road. The nearly 2,000 page bill covers infrastructure improvements—everything from roads to broadband. The package also includes funding for projects that would build up the country’s climate change resilience. Some climate change experts say the budget doesn’t go far enough and other analysis says the bill would not pay for itself. Umair Irfan, staff writer at Vox, walks us through the bill, new fuel economy rules for electric vehicles, a Tesla lithium-ion battery fire, and more science news from the week.          Wait, Am I Going To Need A Booster Shot? Just this week, health officials announced that New York City will require proof of COVID-19 vaccination for some indoor activities, like dining and exercise. It’s the first city to institute this type of policy, and it’s all in an effort to get more people vaccinated, as the Delta coronavirus variant has forestalled efforts to curb the pandemic. Spikes in cases are happening all around the country, just as kids are getting ready to go back to the classroom. This is renewing debates about masks, and prompting lots of questions: Are we going to need booster shots? How much should we worry about breakthrough infections? And is full FDA approval of vaccines going to make a difference for those hesitant to get vaccinated? Joining Ira to break down the latest pandemic quandaries is Céline Gounder, epidemiologist and professor at New York University’s Grossman School of Medicine in New York City.     Local Communities Spar Over Minnesota Oil Pipeline After months of lawsuits, protests, and arrests in northern Minnesota, a controversial oil pipeline is still under construction. Candian energy company Enbridge, Inc., says the Line 3 replacement pipeline, necessary to improve the safety of an aging pipeline.  In 1991, Line 3 ruptured, causing the largest inland oil spill in the United States. The new pipeline will be both higher capacity, and follow a different route past lakes, rivers, and other state waters. But in the midst of a severe state-wide drought, the pipeline’s construction process requires the company to temporarily pump tens of millions of gallons of groundwater. Meanwhile, drilling fluids have been spilled at least once into a nearby river. Science Friday news director John Dankosky talks to two reporters, Minnesota Public Radio’s Kirsti Marohn and Indian Country Today’s Mary Annette Pember, about the water impacts of the pipeline construction, and why communities along the route remain divided about its value. Visit here to read a statement provided by Enbridge Energy.   Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Getting To Know The Fungus Among Us (In Our Guts) Your gut microbiome is composed of more than bacteria—a less populous, but still important, resident is fungi. Many people’s lower digestive tract is home to the yeast Candida albicans, the species implicated in vaginal yeast infections and oral thrush. But new research published in the scientific journal Nature this month suggests that Candida in the gut may also be related to severe cases of inflammatory bowel disease, or IBD. Candida comes in multiple forms: a single-celled, rounded yeast, and a multicellular, branched version, known as the hyphal form. The latter is capable of invading other cells, and is associated with tissue damage, like that of IBD. The research team writes that our immune system reacts to candida by targeting a protein found on that second, invasive state. Conversely, our bodies seem to leave the rounded, yeast form alone.  Better understanding what drives these distinct responses may provide clues to developing a vaccine that could help people with candida-linked health problems. And postdoctoral researcher Kyla Ost tells guest host Roxanne Khamsi that the relationship appears to be mutualistic—that is, the fungi themselves benefit from being managed in this way.  She explains the nuanced relationship she and her colleagues uncovered, and how uncovering more about gut fungi may bring new insights into the relationship between our microbial communities and our health.      COVID And Climate Change Collide At The Olympics The Tokyo Olympics have been underway for a week, with talented athletes competing at their peak. But this year, it’s hard to watch the Olympics without thinking about two of the biggest science stories of the summer: COVID-19, and the record heat and humidity athletes are facing as part of this year’s games. Holding the Olympics during a global pandemic is uncharted territory, and keeping the virus out of the games has been a huge logistical challenge. There are more than 11,000 athletes participating in this summer’s games, coming from 206 nations. Factor in the coaches, staff, press, and service workers, and that’s a lot of people to keep healthy. As if that wasn’t enough, Tokyo is experiencing extreme heat and humidity, consistently reaching 90 degrees Fahrenheit with humidity at about 80%. While the city has always had hot summers, they have gotten worse with climate change. Tokyo’s average annual temperature has risen by more than 5 degrees Fahrenheit since 1900, according to NASA. Athletes have had to take additional measures to keep themselves cool. To tackle these stories, guest host Roxanne Khamsi talks to sports writer Hannah Keyser, from Yahoo Sports, about the Olympics’ COVID-19 protocols, as well as her experience as a reporter covering the games in Tokyo. Then, Roxanne speaks with Scott Delp, professor of bioengineering at Stanford University and director of the Wu Tsai Human Performance Alliance, about athletic performance and safety.   What’s Shaking Below Mars’ Surface? You’ve seen the effects of earthquakes on our planet. The ground shakes, the earth trembles, and if a quake is strong enough, it can bring widespread damage and devastation. But it turns out that ours is not the only quaking planet around—there are quakes caused by geologic activity on Mars too. While Mars doesn’t have plate tectonics like Earth, other processes, from volcanic activity to planetary cooling, can cause tremors in the ground. Seismologists have been using these marsquakes almost like sonar signals through the planet’s interior to provide clues as to what’s going on below the Martian surface.   Several new papers based on the data from the Mars InSight lander were recently published in the academic journal Science. Bruce Banerdt, principal investigator, and Sue Smrekar, deputy principal investigator for the InSight lander, join guest host Roxanne Khamsi to talk about the results and how they compare to Earth geology. Smrekar also gives a preview of the planned VERITAS mission to Venus, which will attempt to deduce some of Venus’ geologic processes from orbit. Smrekar is principal investigator for VERITAS, which might launch in 2027. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.