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Back in November, researchers hailed the dawn of a new era of Alzheimer’s therapies. After decades of failure, a clinical trial finally confirmed that a drug, lecanemab, was able to slow cognitive decline in patients with early stages of the disease. The result may have been modest – a reduction in the decline in patients’ overall mental skills by 27% over 18 months – but it could not be more significant in the journey towards better understanding and treating the disease. Ian Sample speaks to Prof Nick Fox about the clinical trial results, if this could be the first of many new Alzheimer’s therapies, and whether we could one day see a cure.. Help support our independent journalism at theguardian.com/sciencepod

From a fragment of skull in a washing machine to a finger bone found by a dog walker, the forensic anthropologist Prof Dame Sue Black has helped solve many strange and mysterious cases. This year, she will be giving the Royal Institution Christmas lectures, Britain’s most prestigious public science lectures. In them, she’ll be investigating the secret clues hidden in our bodies and how the scientific detective process can be used to identify the living and the dead. Nicola Davis sat down with Black to discuss the lectures, her most memorable cases, and why she didn’t want her daughters to get braces. Madeleine Finlay hears from them both in this Christmas special of Science Weekly. Help support our independent journalism at theguardian.com/sciencepod

As Christmas approaches, many of us will have spent the last few weeks trying to pick out the perfect presents for friends, family and colleagues. For both giver and receiver, exchanging gifts can be filled with delight – or dread, as a smile slowly fades into a look of feigned enthusiasm. But what does science say about how to avoid unwanted gifts and unpleasant surprises? Ian Sample speaks to Julian Givi about his research unwrapping what we all actually want under the tree, and hears his top tips for choosing a winning present every time. Help support our independent journalism at theguardian.com/sciencepod