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In a special edition recorded live at the Hay Festival, Tom Sutcliffe discusses the impact of human ingenuity. From the myth of Frankenstein to geoengineering, he explores how normality and deviancy became entrenched in society. In her latest novel, the award-winning writer Jeanette Winterson moves between 1816, when the young Mary Shelley wrote the great Gothic novel of scientific hubris, Frankenstein, and the present day, exploring the far-reaching consequences of the AI revolution. John Browne, the former CEO of BP, argues against putting the brakes on technological advance. He maintains that civilisation is founded on engineering innovation.Naomi Wolf looks back to the 1857 Obscene Publications Act to pinpoint the moment that law enforced the sexuality morality of the time. She sees reverberations lasting to this day.Producer: Katy Hickman

Dr Joshua Mezrich is a leading transplant surgeon. He tells Andrew Marr how death and life are intimately connected in his field of expertise. And he explains the extraordinary breakthroughs that have emerged in transplant surgery, along with the ethical questions that arise when choosing who will be given the chance of a new beginning. Scientific research needs to be evidence-based. But it can too easily be based on underlying assumptions and biases. The science writer Angela Saini reports on the history - and recent revival - of race science, a field of study that sees race as a biological fact.Caroline Criado Perez exposes the gender biases in medical and scientific research. She argues that women have often been excluded from the data which has had a huge impact on the efficacy of the pills prescribed, and the treatment offered.The latest promise of better healthcare is personalised medicine, which aims to get the right dose to the right patient at the right time. But Richard Ashcroft, Professor of Biomedical Ethics, cautions that grouping patients by their genetic constitution may well create new forms of inequality.Producer: Katy Hickman

Kerry Hudson grew up in all-encompassing and grinding poverty. She is now an acclaimed author, but tells Tom Sutcliffe why she returned home to explore the impact and trap of being lowborn.Howard Brenton’s latest play is loosely inspired by Thomas Hardy’s Jude the Obscure and features a clever, ambitious young woman fighting for an opportunity, yet held back by her background. Will Tanner, director of the think tank Onward, looks at what social mobility - or a lack of it - means in the political sphere. The age at which voters are more likely to vote Conservative than Labour has risen rapidly, and Tanner sees this as both a challenge and an opportunity for all the main parties.The musician and activist Billy Bragg has written about the Three Dimensions of Freedom in which he argues that without equality and accountability, freedom is a mere shadow.Producer: Katy Hickman