Huberman Lab Folgen

This episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We discuss the biology and medical clinical-trial uses of psilocybin, MDMA, ayahuasca, DMT, and LSD. Dr. Johnson teaches us what the clinical trials in his lab are revealing about the potential these compounds hold for the treatment of depression, addiction, trauma, eating disorders, ADHD, and other disorders of the mind. Dr. Johnson describes a typical psychedelic experiment in his laboratory, start to finish, including the conditions for optimal clinical outcomes. And he explains some of the potential hazards and common misconceptions and pitfalls related to psychedelic medicine. Dr. Johnson explains flashbacks, the heightened risks of certain people and age groups using psychedelics and the ever evolving legal and pharmaceutical industry landscape surrounding psychedelics. Dr. Johnson also explains how the scientific study of psychedelics is likely to set the trajectory of psychiatric medicine in the years to come. Dr. Johnson is among a small handful of researchers who have pioneered the clinical study of these powerful compounds. He has unprecedented insight into how they can be woven into other psychiatric treatments, changing ones sense of self and of reality. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Introducing Dr. Matthew Johnson (00:02:27) Sponsors: AG1, LMNT (00:06:40) ‘Psychedelics’ Defined (00:14:09) Hallucinations, Synesthesia, Altered Space-Time Perception (00:19:56) Serotonin & Dopamine  (00:23:50) Ketamine & Glutamate  (00:28:00) An Example Psychedelic Experiment (00:37:30) ‘Letting Go’ with Psychedelics (00:44:10) Our Mind’s Eye (00:48:00) Redefining Your Sense of Self  (00:58:56) Exporting Psychedelic Learnings to Daily Life (01:04:36) Flashbacks (01:12:10) Ayahuasca, & ASMR, Kundalini Breathing (01:15:54) MDMA, DMT (01:26:00) Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis (01:38:15) Micro-Dosing (01:56:45) Risks for Kids, Adolescents & Teenagers; Future Clinical Trials (02:03:40) Legal Status: Decriminalization vs. Legalization vs. Regulation (02:18:35) Psychedelics for Treating Concussion & Traumatic Brain Injury  (02:27:45) Shifting Trends in Psychedelic Research, Academic Culture (02:44:23) Participating in a Clinical Trial, Online Survey Studies, Breathwork  (02:50:38) Conclusions, Subscribing & Supporting the HLP, Supplements Title Card Photo Credit: Mike Blabac Disclaimer

In this episode, I discuss ADHD (Attention-Deficit Hyperactivity Disorder): what it is, the common myths, and the biology and psychology of ADHD. I discuss both behavioral and pharmacologic treatments for ADHD, and brain-machine interface tools. I also discuss behavioral training protocols that can improve focus in people with ADHD and those without ADHD, and for people of different ages. I discuss the role of dopamine in coordinating 'default-mode' and 'task-related' neural networks, attentional "blinks" (lapses of attention) and how to overcome them, and the role of actual blinks in time perception and attention. Finally, I review some of the prescription and over-the-counter compounds for increasing focus such as Adderall, Ritalin, Modafinil and Armodafinil, the racetams, Alpha-GPC and phosphatidylserine and the role of diet for managing ADHD (and the controversies of diet for ADHD). The role of cell phones/technology in ADHD and ADHD-like challenges with focus are also discussed. Throughout, both basic science and clinical scenarios, as well as applicable tools and resources are covered. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Introduction & Note About Diagnosis (00:03:44) Sponsors: AG1, LMNT (00:07:56) ADHD vs. ADD: Genetics, IQ, Rates in Kids & Adults (00:13:00) Attention & Focus, Impulse Control (00:14:57) Hyper-focus  (00:16:45) Time Perception (00:18:25) The Pile System (00:20:00) Working Memory (00:24:10) Hyper-Focus & Dopamine  (00:26:40) Neural Circuits In ADHD: Default Mode Network & Task-Related Networks  (00:32:57) Low Dopamine in ADHD & Stimulant Use & Abuse (00:37:10) Sugar, Ritalin, Adderall, Modafinil & Armodafinil  (00:47:00) Non-Prescribed Adderall, Caffeine, Nicotine (00:49:18) How Stimulants “Teach” the Brains of ADHD Children to Focus (00:52:00) When To Medicate: A Highly Informed (Anecdotal) Case Study (00:56:35) Elimination Diets & Allergies In ADHD (01:04:46) Omega-3 Fatty Acids: EPAs & DHAs  (01:07:00) Modulation vs Mediation of Biological Processes (01:10:50) Attentional Blinks  (01:16:56) Open Monitoring & 17minute Focus Enhancement  (01:22:50) Blinking, Dopamine & Time Perception; & Focus Training  (01:30:10) Reverberatory Neural & Physical Activity (01:33:40) Adderall, Ritalin & Blink Frequency (01:35:00) Cannabis  (01:37:30) Interoceptive Awareness  (01:41:15) Ritalin, Adderall, Modafinil, Armodafinil; Smart Drugs & Caffeine: Dangers (01:48:05) DHA Fatty Acids, Phosphatidylserine (0:1:50:54) Ginko Biloba  (01:51:45) Modafinil & Armodafanil: Dopamine Action & Orexin (01:56:19) Acetylcholine: Circuits Underlying Focus; Alpha-GPC (01:59:04) L-Tyrosine, (PEA) Phenylethylamine  (02:01:23) Racetams, Noopept  (02:05:15) Transcranial Magnetic Stimulation; Combining Technology & Pharmacology  (02:09:14) Smart Phones & ADHD & Sub-Clinical Focus Issues In Adults & Kids (02:14:30) Synthesis/Summary (02:16:10) Support for Podcast & Research, Supplement Resources Title Card Photo Credit: Mike Blabac Disclaimer

In this episode, I discuss what drives hunger and satiety, and the role our brain, stomach, fat and hormones play in regulating hunger and turning off the desire to eat more. I also address how protein is assimilated better early in the day than it is later in the day, and why those using intermittent fasting might want to shift their feeding window to earlier in the day. Then I delve into the topic of disorders of eating: Anorexia Nervosa, where people starve themselves and Bulimia Nervosa where people binge and purge their food. I discuss some common myths about Anorexia such as the role of media images increasing the rates of anorexia and the myth of the "perfectionist" anorexic. I also review the symptoms, and the brain and chemical systems disrupted in this condition. I explain how anorexics become hyperaware of the fat content of foods and develop reflexive habits of fat-hyperawareness. Then I discuss the most effective treatments ranging from family-based models to those that target the habitual nature of low-fat/calorie food choices. I also discuss new more experimental clinical trials on MDMA, Psilocybin and Ibogaine for Anorexia, and both their promise and risks I review the latest work on binge eating disorder and brain stimulation, drug treatments and thyroid disruption in Bulimia and why the treatments for Bulimia are so similar to those for ADHD. Finally, I discuss "cheat days," body dysmorphia and the growing list of novel forms of eating disorders start to finish. As always, science and science-based tools are discussed. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Introduction: Fasting, & Defining Healthy Eating (00:08:55) Morning Protein Is Important  (00:22:21) Sponsors: AG1, LMNT (00:26:29) Defining & Diagnosing Eating Disorders (00:29:00) Anorexia Nervosa (Overview & Myths) (00:33:44) Bulimia (Overview & Myths) (00:37:35) Binge Eating Disorders, EDNOS, OSFEDS, Pica (00:39:44) What is Hunger? What is Satiety? (00:42:00) Neuronal & Hormonal “Accelerators & Brakes” on Eating (00:46:17) Fat, Leptin & Fertility & Metabolic Dysfunctions in Obesity (00:50:30) Why We Overeat (00:55:30) Homeostasis & Reward Systems/Decisions  (00:59:58) Anorexia (01:04:28) The Cholesterol Paradox (01:06:13) Psychological vs. Biological/Genetic Factors in Anorexia (01:09:44) Chemical Imbalances, Serotonergic Treatments (01:12:56) Altered Habits & Rewards in Anorexia: Hyperacuity for Fat Content (01:18:28) Brain Areas for Reward Based Decision Making vs. Habits (01:24:06) Habit-Reward Circuits Are Flipped in Anorexics: Reward for Deprivation (01:28:30) How Do You Break a Habit?  (01:33:23) Family Based Models, Cognitive Behavioral Therapy (01:35:39) MDMA, Psilocybin, Clinical Trials, Ibogaine  (01:40:35) Anabolic vs. Catabolic Exercise, Spontaneous Movements, NEAT (01:43:23) Distorted Self Image in Anorexia  (01:47:54) Bulimia & Binge-Eating, “Cheat Days”, Thyroid Hormone (01:53:05) Inhibitory Control, Impulsivity, Adderall, Wellbutrin (01:58:00) Direct Brain Stimulation: Nucleus Accumbens (02:04:28) Anorexia/Reward. vs Bulimia/Binging   (02:05:45) Healthy Eating Revisited (02:10:55) Synthesis, Body Dysmorphias (02:14:15) Support: Podcast, & Research Studies Title Card Photo Credit: Mike Blabac Disclaimer