When Professor Sir Michael Marmot was a junior doctor he decided that medicine was failed prevention.
To really understand disease you have to look at the society people live in. His major scientific discovery came from following the health of British civil servants over many years. The Whitehall studies, as they're known, challenged the myth about executive stress and instead revealed that, far from being 'tough at the top', it was in fact much tougher for those lower down the pecking order. This wasn't just a matter of rich or poor, or even social class. What Marmot showed was the lower your status at work, the shorter your lifespan. Mortality rates were three times higher for those at the bottom than for those at the top. The unpleasant truth is that your boss will live longer than you.What's more, this social gradient of health, or what he calls Status Syndrome, isn't confined to civil servants or to the UK but is a global phenomenon. In conversation with Jim Al-Khalili Michael Marmot reveals what inspires and motivates his work.Producer: Geraldine Fitzgerald.
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The Life Scientific Folgen
Professor Jim Al-Khalili talks to leading scientists about their life and work, finding out what inspires and motivates them and asking what their discoveries might do for us in the future
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Folge vom 01.11.2011Sir Michael Marmot
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Folge vom 18.10.2011Steven PinkerCognitive psychologist, Steven Pinker, has been dubbed "science's agent provocateur". Pinker studies how the mind works. Presenter Jim al-Khalili wants to find out how his mind works. Pinker replies: "as a psychologist you look at your own life as data and say geez that's what I'm like". From verbs to violence, he's author of several books that many say are mind-changing. He's now something of a science superstar, but his early experiments with electrodes on rats didn't quite go according to plan: "I realised then that that kind of science required a level of meticulousness that I just didn't have". So instead of studying neuroscience, he became a cognitive psychologist. Now perhaps better known for his writing than his science, he shot to fame with his book The Language Instinct, based on his early studies of how children tackle irregular verbs, for example saying "holded" not held, and "digged" instead of dug. These cute sounding mistakes are proof that three year olds are grammatical geniuses, he says. And he met his wife Rebecca Goldstein over an irregular verb. Later, Pinker set the cat among the social science pigeons by stressing the importance of nature rather than nurture: an assertion that led to some bitter arguments with, among others, the psychologist Oliver James. He readily admits that genes aren't everything: he's decided not to have children and says "if my genes don't like it, they can go jump in the lake". But he says, "there's a phobia of genetics that it's time to get over". Our failure to even think about genetic influences has given us a false impression of the amount of influence parents have over their children: it's skewed the science. Parents like to think that they mould and shape their children in certain ways but Pinker argues, as long as children are not abused, parenting makes little difference to how they turn out at 18. His most recent book 'The Better Angels of Our Nature' is about the decline in global violence from 8500 BC. Despite two World Wars, Vietnam, Kosovo, Iraq, Darfur and many others, Pinker asserts that we are living in the most peaceful times ever and wants to know why our better angels triumph over our inner demons. Is he now showing the better angel of his Nature? Each week on The Life Scientific, Jim al-Khalili invites a leading scientist to tell us about their life and work: he wants to get under their skin and into their minds. And he'll ask what their discoveries might do for us. He talks to Nobel laureates as well as the next generation of beautiful minds and finds out what inspired them to do science in the first place and what motivates them to keep going. Fellow scientists will comment on their work, putting it in context and offering alternative perspectives. Future guests include: astronomer Jocelyn Bell-Burnell; the brains behind the Human Genome Project, John Sulston; Molly Stevens, a tissue engineer who's work growing bones could mean the end of metal pins for broken legs; Hugh Montgomery, who discovered the fitness gene. Themes and ideas from the interviews will be explored on The Life Scientific website, which will aggregate some of the best Radio 4 Science archive around the topics discussed in the programmes.
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Folge vom 11.10.2011Paul NurseTheir work is changing the world we live in, but what do we really know about their lives beyond the lab?Each week on The Life Scientific, Jim Al-Khalili, Professor of Physics at Surrey University, invites a leading scientist to tell us about their life and work. He wants to get under their skin and into their minds; to find out what first inspired them towards their field of research and what motivates them to keep going when the evidence seems to be stacking up against their theories. And he'll ask what their ideas and discoveries will do for us. He'll talk to Nobel laureates as well as the next generation of beautiful minds, finding out what inspired them to do science in the first place and what motivates them to keep going. The programme will also feature short drop-ins from fellow scientists. Some will comment on our guest's early career, the implications of their discoveries, or offer alternative perspectives. In this first programme, Jim talks to geneticist Paul Nurse, arguably the most powerful scientist in Britain today. Nurse's interest in science was sparked by the early days of the space race, when one night as a boy, he chased Sputnik down the road in his pyjamas, in a vain attempt to catch up with the Russian satellite as it passed overhead. Nurse, a Nobel Laureate and President of the Royal Society is now firmly part of the science establishment but his upbringing and early academic life was far from conventional. Brought up by working class parents, in North London, Nurse struggled at first to even get accepted by any University. According to one of his tutors (who we'll hear from in the programme) Nurse didn't exactly shine as an undergraduate, either. But these experiences taught him to be self reliant, determined and not afraid of failure.It was a attitude that paid off. In 2001, Nurse shared the Nobel Prize for Physiology or Medicine for his research on how cells divide, a process which is not only fundamental to all living things but has major implications for understanding and treating diseases like cancer.His rise was, some say, meteoric. But it's not how he sees it, especially in the early days: " I did have a lot of trouble getting a proper job". Now President of one of the oldest and most respected scientific institutions in the world, Nurse's career has been far from predictable, and at times, controversial. Yet the same could be said for his personal life, when in his 50s, he was hit with a major revelation that would change forever how he viewed his past. Confirmed guests on future programmes include the cognitive scientist Stephen Pinker; Astronomer Jocelyn Bell-Burnell; the brains behind the Human Genome Project, John Sulston; Epidemiologist Michael Marmot, neuroscientist Colin Blakemore and Molly Stevens, a tissue engineer whose work growing bones could mean the end of metal pins for broken legs; Producers: Anna Buckley and Geraldine Fitzgerald.