Huberman Lab Folgen

In this episode, I discuss how hormones such as testosterone and estrogen and their derivatives impact the early development of the brain and body and their maturation. I review published data on environmental factors shown to powerfully alter hormone pathways in animals and humans and the effects of cannabis, alcohol and cell phones on testes, sperm, ovaries and hormones. I describe the predictable relationship between genes, beard growth and balding patterns, and the importance of estrogen for brain development in people of all chromosomal sexes. Finally, I discuss how the hormones we are exposed to in the womb shape the relative length of our finger digits, the sounds our ears make (yes you read that correctly), and how those correlate with people's self-reports of their sexual preferences. As always, basic information and tools are discussed. Access the full show notes, including referenced articles, resources and more at hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Waking Up: https://www.wakingup.com/huberman Momentous: https://www.livemomentous.com/huberman Timestamps (00:00:00) Introduction (00:00:30) AG1, LMNT & Waking Up (00:06:47) Announcement: Mood Meter App Works Again (00:08:00) Maximizing Learning from the Podcast (00:10:00) New Non-Sleep Deep Rest Protocol, Spanish Subtitles (00:11:35) Sexual Differentiation: Hormones, Neurons & Behavior (00:14:15) Hormones Basics (00:15:26) Sperm Meets Egg, Chromosomal Sex, Gonadal Sex, (00:17:50) Y Chromosome Inhibition of Feminization (00:19:00) Placenta Is An Endocrine (Hormone-Producing) Organ, Adrenal Testosterone (00:19:45) Hormonal Sex, Morphological Sex (00:21:04) Hormones Fast & Slow, Sex Steroids Can Turn On Genes (00:23:06) Masculinization, Feminization, Demasculinization, Defeminization (00:23:42) Primary Sexual Characteristics: DHT Drives Penis Development (00:27:03) Secondary Sexual Characteristics (00:27:43) Penis Sprouting: Guevedoces (00:31:25) Estrogen, NOT Testosterone, Masculinizes The Brain (00:33:15) Breast Development In Males: Aromatase; Puberty, & Steroids in Athletes (00:34:50) Estrogen Powerfully Controls Brain Development In All Individuals (00:35:19) Avoiding Hormonal Disruption In Children & Adults: Specific Oils, Creams, Etc. (00:39:00) Environmental Endocrine Disruptors, Sperm Count Decline, Vincloziline (00:44:20) Androgen Insensitivity Syndrome: Hormones Need Receptors, SARMS (00:48:41) Estrogen Establishes “Masculine” Brain Circuits, Testosterone (00:49:42) Cannabis, Alcohol: In Babies, Puberty & Adults (00:56:25) Cell Phone Technology: Effects On Hormones, Ovaries, & Testicles (01:02:33) Beards & Baldness Patterns Around the World, DHT, 5-alpha-reductase (01:06:39) Creatine & DHT/Hair Loss (01:08:20) Predicting Aging Rates By Pubertal Rates (01:10:04) Hyenas, Baseball, & Jumbo Clitorises: Androstenedione (01:14:26) Intersex Moles (01:15:40) Marijuana Plants, Pollens: Plant-To-Animal “Warfare” (01:20:08) Finger Length Ratios, Prenatal Hormone Exposure & Sexual Orientation (01:29:13) Brain Dimorphisms with Sexual Orientation (01:32:00) “Older Brother Effects”: Male Fetuses Might Change Mothers & Subsequent Brothers (01:35:06) The Path Forward & A Warning (01:35:55) Support & Your Questions Title Card Photo Credit: Mike Blabac Disclaimer

In this episode, I discuss the biology of emotions and moods in the context of relationships. I focus on the science of how early infant-caregiver attachment, combined with adolescence and puberty shape our adult patterns of attachment. I explain the three universal aspects of emotions, the reality of right-brain versus left-brain personalities, and how the roots of adult attachment are also grounded in specific aspects of puberty. I review what factors determine when puberty starts and ends, and the role of oxytocin and other chemicals in controlling how we perceive and remember others. As always, I refer to various practical tools including new tools for understanding and predicting our emotions before they occur, and neurochemicals that shape human connection. Access the full show notes, including referenced articles, resources and more, at hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Waking Up: https://www.wakingup.com/huberman Momentous: https://www.livemomentous.com/huberman Timestamps (00:00:00) Introduction (00:00:32) Sponsors: AG1, LMNT & Waking Up (00:05:10) Announcing New Cost-Free Resources: Captions, NSDR Link (00:07:40) Emotions: Subjective Yet Tractable (00:10:53) To Understand Your Emotions: Look At Infancy & Puberty (00:15:21) Your First Feeling Was Anxiety (00:17:36) What Are “Healthy Emotions”? (00:19:03) Digital Tool For Predicting Your Emotions: Mood Meter App (00:21:08) The Architecture Of A Feeling: (At Least) 3 Key Questions To Ask Yourself (00:24:00) You Are An Infant: Bonds & Predictions (00:27:57) Attachment Style Hinges On How You Handle Disappointment (00:32:40) “Glue Points” Of Emotional Bonds: Gaze, Voice, Affect, Touch, (& Written) (00:36:34) “Emotional Health”: Awareness of the Interoceptive-Exteroceptive Dynamic (00:37:50) An Exercise: Controlling Interoceptive-Exteroceptive Bias (00:42:19) Getting Out Of Your Head: The Attentional Aperture (00:46:59) Puberty: Biology & Emotions On Deliberate Overdrive (00:47:58) Bodyfat & Puberty: The Leptin Connection (00:50:34) Pheromones: Mates, Timing Puberty, Spontaneous Miscarriage (00:54:37) Kisspeptin: Robust Trigger Of Puberty & Performance Enhancing Agent (00:58:26) Neuroplasticity Of Emotions: Becoming Specialists & Testing Emotional Bonds (01:00:25) Testing Driving Brain Circuits For Emotion: Dispersal (01:07:48) Science-Based Recommendations for Adolescents and Teens: The Autonomy Buffet (01:11:05) “Right-Brain Versus Left-Brain People”: Facts Versus Lies (01:14:18) Left Brain = Language, Right Brain = Spatial Awareness (01:16:15) How To Recognize “Right Brain Activity” In Speech: Prosody (01:18:32) Oxytocin: The Molecule of Synchronizing States (01:20:09) Mirror Neurons: Are Not For “Empathy”, Maybe For Predicting Behavior (01:23:00) Promoting Trust & Monogamy (01:27:00) Ways To Increase Oxytocin (01:28:34) Vasopressin: Aphrodisiac, Non-Monogamy and Anti-Bed-Wetting Qualities (01:30:43) Bonding Bodies, Not Just Minds: Vagus Nerve, Depression Relief Via the Body (01:35:18) A Powerful Tool For Enhancing Range & Depth of Emotional Experience (01:30:43) MDMA and Other Psychedelic Compounds: Building A Framework (01:38:54) Roundup, Various Forms of Support Title Card Photo Credit: Mike Blabac Disclaimer

This episode explains the science of motivation and drive. I describe how dopamine-- a chemical we all make in our brain, underlies our desire for and pursuit of our goals, as well as our capacity to move and experience pleasure. I describe how we can leverage specific behaviors, reward schedules and dopamine-prolactin balance to help ensure we can maintain motivation and capacity for pleasure over the long term. I also discuss dopamine in the context of ADHD, craving and addiction, and some absolutely amazing results about specificity of drug effects based purely on belief. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Waking Up: https://www.wakingup.com/huberman Momentous: https://www.livemomentous.com/huberman Timestamps (00:00:00) Introduction (00:00:30) Sponsors: AG1, LMNT, Waking Up (00:04:22) Announcement: Spanish Subtitles (00:05:06) Emotions, Addiction & Mindset (00:06:22) Motivation & Movement: The Dopamine Connection (00:07:29) A Double-Edged Dopamine Blade (00:08:56) Dopamine Fundamentals: Precursor to Adrenalin (00:10:15) The Reward Pathway: An Accelerator & A Brake (00:12:10) Motivation= Pleasure Plus Pain (00:14:14) The Dopamine Staircase: Food, Sex, Nicotine, Cocaine, Amphetamine (00:16:15) Subjective Control of Dopamine Release (00:17:40) Social Media and Video Games (00:18:15) Addiction & Dopamine: Progressively Diminishing Returns (00:18:48) Novelty, Sensation-Seeking & Anticipation (00:20:15) Craving: Part Pain, Part Pleasure & Pain Always Prevails (00:23:11) Desire Scales With Pain: The Yearning Function (00:24:43) The Croissant Craving Circuit (00:25:45) “Here and Now” Molecules: Serotonin, Bliss & Raphe Nucleus (00:26:26) In Your Skin Or Out In the World (00:27:25) Cannabinoids Lethargy & Forgetfulness (00:28:15) The Almond Meditation (00:29:30) Drugs That Shift Exteroception Versus Interoception (00:30:36) Emotional Balance, Active & Passive Manipulation (00:32:36) Procrastination: Leveraging Stress, Breathing, Caffeine, L-Tyrosine, Prescription Drugs (00:37:04) When Enough Is Never Enough; How Dopamine Undermines Itself (00:38:58) Dopamine-Prolactin Dynamics: Sex, Reproduction & Refractory Periods (00:40:30) The Coolidge Effect: Novelty-Induced Suppression of Prolactin (00:42:22) Vitamin B6, Zinc As Mild Prolactin Inhibitors (00:43:25) Schizophrenia, Dopamine Hyperactivity and Side Effects of Anti-Dopaminergic Drugs (00:45:08) Prolactin, Post-Satisfaction “Lows” & Extending the Arc of Dopamine (00:48:00) The Chemistry of “I Won, But Now What?” (00:49:00) Healthy Emotional Development: Child and Parent (00:50:03) Never Say “Maybe” (Reward Prediction Error) (00:52:02) Surprise! (00:52:59) Are You Suppressing Your Drive and Motivation By Working Too Late? (00:54:50) Disambiguating Pleasure and Drive: Dopamine Makes Us Anti-Lazy (00:58:00) Beta-Phenylethylamine (PEA), & Acetyl L-Carnitine (01:00:00) Attention Deficit Disorders, Cal Newport Books, Impulsivity & Obesity (01:03:55) Leveraging Dopamine Schedules (01:05:22) Subjective Control of Dopamine and Drug Effects: The “Adderall” Experiment (01:09:03) Caffeine May Protect Dopamine Neurons, Methamphetamine Kills Them (01:10:57) Nicotine: Dopamine, Possible Neuroprotection, Prolactin Increase (01:11:53) Gambling, Intermittent Reinforcement, & Persistent Goal Seeking (Bad and Good) (01:14:14) Intermittent Halting of Celebration; Enjoy Your Wins, But Not All of Them (01:18:38) A Story Example of Intermittent Reward to Maintain Long-Term Drive and Motivation (01:21:25) Corrections & Notes About Spanish Captions & Other Languages Soon (01:24:00) Synthesis & Framework, Zero-Cost Support & A Note About Sponsors Title Card Photo Credit: Mike Blabac Disclaimer